Journal: BMC Neurology

Article Title: Study design of PANGAEA 2.0, a non-interventional study on RRMS patients to be switched to fingolimod

doi: 10.1186/s12883-016-0648-6

Figure Lengend Snippet: Study design of PANGAEA 2.0. The study involves an evaluation of disease activity to identify sub-optimally treated RRMS patients (V0), the switch of MS therapy to fingolimod (Gilenya®; V1), and a 3-year observational phase (V2–V14) to assess treatment response in several functional domains. A sub-study analyzes the benefits of a standardized quantitative evaluation of routine MRI scans by a central reading facility (NEDA-4: No Evidence of Disease Activity-4; 2D FDS: 2D Focused Disability Scale)

Article Snippet: In the PANGAEA 2.0 sub-study, 100 MS centers will submit MRI data obtained in accordance with a standardized protocol to a central reading facility (Mediri GmbH, Heidelberg) for qualitative and quantitative evaluation (Fig. ).

Techniques: Activity Assay, Functional Assay

Journal: BMC Neurology

Article Title: Study design of PANGAEA 2.0, a non-interventional study on RRMS patients to be switched to fingolimod

doi: 10.1186/s12883-016-0648-6

Figure Lengend Snippet: Patient evaluation in PANGAEA 2.0. The software-based MS management system MSDS 3D is supporting patient management (1) and assists physicians in executing all evaluations required for MS diagnosis, treatment initiation, assess safety, and long-term treatment outcome. Patient status (2) is evaluated by means of the 2D Focused Disability Scale (2D FDS) that comprises clinical and subclinical measures representing both the patient’s and the physician’s perspectives (UKNDS: United Kingdom Neurological Disability Scale; FSMC: Fatigue Scale for Motor Fatigue and Cognitive Functions; WPAI-MS: Work Productivity and Activities Impairment; EQ-5D: EuroQuol-5D; EDSS: Expanded Disability Status Scale; SDMT: Symbol Digit Modality Test; CGI: Clinical Global Impression). Standardized quantitative evaluation of routine MRI scans (3) is performed by a central reading facility. The MRI protocol for MRI acquisition and the parameters for quantitative MRI evaluation of lesion load, lesion volume and brain volume are shown. Propose patient evaluation in PANGAEA 2.0

Article Snippet: In the PANGAEA 2.0 sub-study, 100 MS centers will submit MRI data obtained in accordance with a standardized protocol to a central reading facility (Mediri GmbH, Heidelberg) for qualitative and quantitative evaluation (Fig. ).

Techniques: Software, Biomarker Discovery

Journal: Journal of Cardiovascular Magnetic Resonance

Article Title: Peak velocity estimation in aortic stenosis patients using a fast three-directional two-dimensional phase contrast technique in a single breath-hold: comparison to unidirectional phase contrast MRI and transthoracic echocardiography

doi: 10.1186/1532-429X-18-S1-P335

Figure Lengend Snippet: (A/B) Differences in velocity estimation between 1Dir and 3Dir PC-MRI . While 1Dir PC-MRI computes velocity in one direction (Z), 3Dir PC-MRI simultaneously computes velocities in 3 directions (X, Y and Z) in a single breath-hold. (C/D) Bland-Altman plots of comparison between peak velocities from TTE versus 1Dir PC-MRI, and TTE versus 3Dir PC-MRI.

Article Snippet: 1Dir (TR/TE = 49/2.3 ms, α = 250, BW = 420Hz/px, segmented GRE) and 3Dir PC-MRI (TR/TE = 49/2.8 ms, α = 150, BW = 1860 Hz/px, segmented EPI) data were acquired at 3 levels above the aortic valve using a 1.5T Siemens Avanto.

Techniques: Comparison

Journal: Journal of Cardiovascular Magnetic Resonance

Article Title: Peak velocity estimation in aortic stenosis patients using a fast three-directional two-dimensional phase contrast technique in a single breath-hold: comparison to unidirectional phase contrast MRI and transthoracic echocardiography

doi: 10.1186/1532-429X-18-S1-P335

Figure Lengend Snippet: Correlations between 1Dir, 3Dir PC-MRI and SSFP cine imaging stroke volume at different acquisition levels above the aortic valve. A positive bias was observed for 1Dir PC-MRI while a smaller negative bias was observed for 3Dir PC-MRI.

Article Snippet: 1Dir (TR/TE = 49/2.3 ms, α = 250, BW = 420Hz/px, segmented GRE) and 3Dir PC-MRI (TR/TE = 49/2.8 ms, α = 150, BW = 1860 Hz/px, segmented EPI) data were acquired at 3 levels above the aortic valve using a 1.5T Siemens Avanto.

Techniques: Imaging

Journal: NeuroImage

Article Title: A face-off of MRI research sequences by their need for de-facing

doi: 10.1016/j.neuroimage.2023.120199

Figure Lengend Snippet: Image Types Tested. All sequences used Siemens 3T Prisma scanners unless otherwise noted.

Article Snippet: Resting-state functional MRI , Siemens 2D EPI BOLD sequence (TR/TE 607/32 ms, flip angle 50°, fat suppression ON, and 8x slice acceleration with 2.5 mm isotropic voxels, for 9 minutes. For face reconstructions, we applied motion correction with SPM12, then averaged across all frames to produce a single 3D volume for surface extraction. For advanced face reconstructions, we used a 3D T2-w template to fill-in missing regions. We also repeated these experiments using the first volume rather than a motion-corrected average, and results were extremely similar (data not presented)..

Techniques: Sequencing, Diffusion-based Assay, Imaging, Functional Assay, Extraction, Derivative Assay, Synthesized